LAMTOR1 Polyclonal Antibody (20 μl)  

LAMTOR1 Polyclonal Antibody (20 μl)  

Cat. #: 4151S
Availability: In Stock
$119.00
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Product Category:   Knockdown Validated Polyclonal Antibody
Synonyms:   Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 1; Protein Associated With DRMs And Endosomes; Late Endosomal/Lysosomal Adaptor And MAPK And MTOR Activator 1; P27kip1 Releasing Factor From RhoA; P27Kip1-Releasing Factor From RhoA; Ragulator Complex Protein LAMTOR1; Lipid Raft Adaptor Protein P18; P27RF-Rho; C11orf59; PDRO; Chromosome 11 Open Reading Frame 59; Ragulator Complex Protein PDRO; RhoA Activator C11orf59; Ragulator1; P18
UniProt Entry:   Q6IAA8 
NCBI Gene Entry:   55004 
Molecular Weight:   18 kDa 
Clonality:   Rabbit polyclonal antibody
Species Reactivity:   Human
Applications:   IC
Recommended Dilution:   IC 1:50
Immunogen:   Recombinant fragment of human LAMTOR1
Isotype:   Rabbit IgG 
Storage Buffer:   Supplied in PBS (pH 7.5) containing 50 µg/ml BSA, 50% glycerol, and 0.01% sodium azide  
Storage:   At –20°C
Background:   The Ragulator complex is comprised of three proteins, C11orf59, ROBLD3, and MAPKSP1, which targets mTORC1 to lysosomal surfaces. This normal endosomal trafficking is taken advantage of by certain viruses, including coronavirus, which has increased replication when C11orf59 is interfered with. C11orf59 is positively regulated by cellular cholesterol depletion and negatively regulated by cellular cholesterol loading. It is involved in LDL uptake and cholesterol homeostasis. C11orf59 and PPAR-alpha work together to control lipid and carbohydrate metabolism in diabetes. Nearly all effects of C11orf59 are associated with mTORC1 kinase growth promotion, and disregulation of the normal mTOR pathway.
Documents: Please contact us to request the manual

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