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Product Category: | Knockdown Validated Polyclonal Antibody |
Synonyms: | AKT1 Substrate 1; 40 kDa Proline-Rich AKT Substrate; Proline-Rich AKT1 Substrate 1; PRAS40; Proline-Rich Akt Substrate, 40 kDa; AKT1 Substrate 1 (Proline Rich); AKT1 Substrate 1 (Proline-Rich); Lobe |
UniProt Entry: | Q96B36 |
NCBI Gene Entry: | 84335 |
Molecular Weight: | 40 kDa |
Clonality: | Rabbit polyclonal antibody |
Species Reactivity: | Human |
Applications: | WB |
Recommended Dilution: | WB 1:1000 |
Immunogen: | Recombinant fragment of human AKT1S1 |
Isotype: | Rabbit IgG |
Storage Buffer: | Supplied in PBS (pH 7.5) containing 50 µg/ml BSA, 50% glycerol, and 0.01% sodium azide |
Storage: | At –20°C |
Background: | AKT1S1 is a substrate and potential regulator of mammalian target of rapamycin (mTOR), a serine/threonine kinase that regulates cell growth and cell cycle, and a negative regulator of autophagy. Treatment with the insulin-like growth factor-1 (IGF1) can induce the phosphorylation of AKT1S1 via the PI3K/AKT signaling pathway in PC12 cells. |
Documents: | Please contact us to request the manual |