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Product Category: | Knockdown Validated Polyclonal Antibody |
Synonyms: | Autophagy Related 7; Ubiquitin-Activating Enzyme E1-Like Protein; Ubiquitin-Like Modifier-Activating Enzyme ATG7; ATG12-Activating Enzyme E1 ATG7; APG7L; HAGP7; ATG7 Autophagy Related 7 Homolog (S. Cerevisiae); APG7 Autophagy 7-Like (S. Cerevisiae); Autophagy-Related Protein 7; APG7 Autophagy 7-Like; APG7-LIKE; APG7-Like; GSA7 |
UniProt Entry: | O95352 |
NCBI Gene Entry: | 10533 |
Molecular Weight: | 78 kDa |
Clonality: | Rabbit polyclonal antibody |
Species Reactivity: | Human |
Applications: | WB |
Recommended Dilution: | WB 1:1000 |
Immunogen: | Recombinant fragment of human ATG7 |
Isotype: | Rabbit IgG |
Storage Buffer: | Supplied in PBS (pH 7.5) containing 50 µg/ml BSA, 50% glycerol, and 0.01% sodium azide |
Storage: | At –20°C |
Background: | ATG7 gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. |
Documents: | Request a manual/MSDS |