ARNT Polyclonal Antibodies  (20 μl)

ARNT Polyclonal Antibodies  (20 μl)

Cat. #: 1657S
Availability: In Stock
$119.00
-+
Product Category:   Knockdown Validated Polyclonal Antibody
Synonyms:   Aryl Hydrocarbon Receptor Nuclear Translocator; Class E Basic Helix-Loop-Helix Protein 2; Dioxin Receptor, Nuclear Translocator; HIF-1-Beta; HIF1-Beta; BHLHe2; Hypoxia-Inducible Factor 1, Beta Subunit; Hypoxia-Inducible Factor 1-Beta; ARNT Protein; HIF-1beta; HIF1BETA; BHLHE2; HIF1B; TANGO
UniProt Entry:   P27540 
NCBI Gene Entry:   405
Molecular Weight:   87 kDa
Clonality:   Rabbit polyclonal antibody
Species Reactivity:   Human
Applications:   WB
Recommended Dilution:   WB 1:1000
Immunogen:   Recombinant fragment of human ARNT   
Isotype:   Rabbit IgG 
Storage Buffer:   Supplied in PBS (pH 7.5) containing 50 µg/ml BSA, 50% glycerol, and 0.01% sodium azide  
Storage:   At –20°C
Background:   AhR, ARNT1, ARNT2 and BMAL1 are members of a family of transcription factors that contain a basic helix-loop-helix motif and a common "PAS" motif. The aromatic (aryl) hydrocarbon receptor, AhR, is a ligand dependent transcription factor that interacts with specific DNA sequences termed xenobiotic responsive elements (XREs) to activate several genes including CYP1A1, glutathione S-transferase Ya subunit and DT-diaphorase. The Ah receptor nuclear translocator proteins (Arnt 1 or Arnt 2) are required for ligand-dependent nuclear translocation of the Ah receptor and are also necessary for Ah receptor binding to the XRE element. BMAL1 (Brain and Muscle Arnt-like protein 1), also designated Arnt 3, TIC, JAP3 or MOP-3, has been shown to dimerize with Clock and bind to the promoter region of mPer1, suggesting that this protein plays a role in regulation of circadian oscillation in mammals.
Documents: Please contact us to request the manual

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