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Product Category: | Knockdown Validated Polyclonal Antibody |
Synonyms: | Aryl Hydrocarbon Receptor Nuclear Translocator; Class E Basic Helix-Loop-Helix Protein 2; Dioxin Receptor, Nuclear Translocator; HIF-1-Beta; HIF1-Beta; BHLHe2; Hypoxia-Inducible Factor 1, Beta Subunit; Hypoxia-Inducible Factor 1-Beta; ARNT Protein; HIF-1beta; HIF1BETA; BHLHE2; HIF1B; TANGO |
UniProt Entry: | P27540 |
NCBI Gene Entry: | 405 |
Molecular Weight: | 87 kDa |
Clonality: | Rabbit polyclonal antibody |
Species Reactivity: | Human |
Applications: | WB |
Recommended Dilution: | WB 1:1000 |
Immunogen: | Recombinant fragment of human ARNT |
Isotype: | Rabbit IgG |
Storage Buffer: | Supplied in PBS (pH 7.5) containing 50 µg/ml BSA, 50% glycerol, and 0.01% sodium azide |
Storage: | At –20°C |
Background: | AhR, ARNT1, ARNT2 and BMAL1 are members of a family of transcription factors that contain a basic helix-loop-helix motif and a common "PAS" motif. The aromatic (aryl) hydrocarbon receptor, AhR, is a ligand dependent transcription factor that interacts with specific DNA sequences termed xenobiotic responsive elements (XREs) to activate several genes including CYP1A1, glutathione S-transferase Ya subunit and DT-diaphorase. The Ah receptor nuclear translocator proteins (Arnt 1 or Arnt 2) are required for ligand-dependent nuclear translocation of the Ah receptor and are also necessary for Ah receptor binding to the XRE element. BMAL1 (Brain and Muscle Arnt-like protein 1), also designated Arnt 3, TIC, JAP3 or MOP-3, has been shown to dimerize with Clock and bind to the promoter region of mPer1, suggesting that this protein plays a role in regulation of circadian oscillation in mammals. |
Documents: | Please contact us to request the manual |