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Product Category: | Knockdown Validated Polyclonal Antibody |
Synonyms: | Histone Deacetylase 4; EC 3.5.1.98; HD4; Brachydactyly-Mental Retardation Syndrome; Histone Deacetylase A; KIAA0288;HA6116; HDAC-4; HDAC-A; HDACA; AHO3; BDMR |
UniProt Entry: | P56524 |
NCBI Gene Entry: | 9759 |
Molecular Weight: | 140 kDa |
Clonality: | Rabbit polyclonal antibody |
Species Reactivity: | Human |
Applications: | WB |
Recommended Dilution: | WB 1:1000 |
Immunogen: | Recombinant fragment of human HDAC4 |
Isotype: | Rabbit IgG |
Storage Buffer: | Supplied in PBS (pH 7.5) containing 50 µg/ml BSA, 50% glycerol, and 0.01% sodium azide |
Storage: | At –20°C |
Background: | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. |
Documents: | Request a manual/MSDS |