Your shopping cart is empty!
Product Category: | Knockdown Validated Monoclonal Antibody |
Synonyms: | Caspase 3; Caspase 3, Apoptosis-Related Cysteine Peptidase; Caspase 3, Apoptosis-Related Cysteine Protease; SREBP Cleavage Activity 1; Cysteine Protease CPP32; Protein Yama; EC 3.4.22.56; Caspase-3; Apopain; CASP-3; CPP-32; CPP32; SCA-1; PARP Cleavage Protease; Procaspase3; EC 3.4.22; CPP32B |
UniProt Entry: | P42574 |
NCBI Gene Entry: | 836 |
Molecular Weight: | 17,19,35 kDa |
Clonality: | Rabbit monoclonal antibody |
Species Reactivity: | Human |
Applications: | WB |
Recommended Dilution: | WB 1:1000 |
Immunogen: | Recombinant fragment of human CASP3 |
Isotype: | Rabbit IgG |
Storage Buffer: | Supplied in PBS (pH 7.5) containing 50 µg/ml BSA, 50% glycerol, and 0.01% sodium azide |
Storage: | At –20°C |
Background: | CASP3 gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. |
Documents: | Please contact us to request the manual |