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Product Category: | Knockdown Validated Polyclonal Antibody |
Synonyms: | DNA Methyltransferase 3 Alpha; DNA (Cytosine-5-)-Methyltransferase 3 Alpha; DNA (Cytosine-5)-Methyltransferase 3A; DNA MTase HsaIIIA; EC 2.1.1.37; M.HsaIIIA; DNA Cytosine Methyltransferase 3A2; DNA Methyltransferase HsaIIIA; DNMT3A2; Dnmt3a; TBRS |
UniProt Entry: | Q9Y6K1 |
NCBI Gene Entry: | 1788 |
Molecular Weight: | 130, 95, 85 kDa |
Clonality: | Rabbit polyclonal antibody |
Species Reactivity: | Human |
Applications: | WB |
Recommended Dilution: | WB 1:1000 |
Immunogen: | Recombinant fragment of human DNMT3A |
Isotype: | Rabbit IgG |
Storage Buffer: | Supplied in PBS (pH 7.5) containing 50 µg/ml BSA, 50% glycerol, and 0.01% sodium azide |
Storage: | At –20°C |
Background: | CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. DNMT3A gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms. |
Documents: | Request a manual/MSDS |