DNMT3A Polyclonal Antibody (20 μl)

DNMT3A Polyclonal Antibody (20 μl)

Cat. #: 2531S
Availability: In Stock
$119.00
-+
Product Category:    Knockdown Validated Polyclonal Antibody
Synonyms:    DNA Methyltransferase 3 Alpha; DNA (Cytosine-5-)-Methyltransferase 3 Alpha; DNA (Cytosine-5)-Methyltransferase 3A; DNA MTase HsaIIIA; EC 2.1.1.37; M.HsaIIIA; DNA Cytosine Methyltransferase 3A2; DNA Methyltransferase HsaIIIA; DNMT3A2; Dnmt3a; TBRS
UniProt Entry:    Q9Y6K1
NCBI Gene Entry:     1788
Molecular Weight:    130, 95, 85 kDa
Clonality:    Rabbit polyclonal antibody
Species Reactivity:    Human
Applications:    WB
Recommended Dilution:    WB 1:1000
Immunogen:    Recombinant fragment of human DNMT3A
Isotype:    Rabbit IgG 
Storage Buffer:    Supplied in PBS (pH 7.5) containing 50 µg/ml BSA, 50% glycerol, and 0.01% sodium azide  
Storage:    At –20°C
Background:    CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. DNMT3A gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.
Documents:    Request a manual/MSDS

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