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Product Category: | Knockdown Validated Polyclonal Antibody |
Synonyms: | Integrin Subunit Alpha 4; Alpha 4 Subunit Of VLA-4 Receptor;CD49 Antigen-Like Family Member D; VLA-4 Subunit Alpha;Integrin Alpha-IV; Integrin Alpha-4; CD49D; Integrin, Alpha 4 (Antigen CD49D, Alpha 4 Subunit Of VLA-4 Receptor); Very Late Activation Protein 4 Receptor, Alpha 4 Subunit; Antigen CD49D, Alpha-4 Subunit Of VLA-4 Receptor; 269C Wild Type;CD49d Antigen; Antigen CD49D; IA4 |
UniProt Entry: | P13612 |
NCBI Gene Entry: | 3676 |
Molecular Weight: | 70, 140, 150kDa |
Clonality: | Rabbit polyclonal antibody |
Species Reactivity: | Human |
Applications: | IC |
Recommended Dilution: | IC 1:100 |
Immunogen: | Recombinant fragment of human ITGA4 |
Isotype: | Rabbit IgG |
Storage Buffer: | Supplied in PBS (pH 7.5) containing 50 µg/ml BSA, 50% glycerol, and 0.01% sodium azide |
Storage: | At –20°C |
Background: | ITGA4 gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. |
Documents: | Request a manual/MSDS |