NOTCH2 Polyclonal Antibody (20 μl)  

Cat. #: 5571S
Availability: In Stock
$119.00
-+
Product Category:   Knockdown Validated Polyclonal Antibody
Synonyms:   Notch Receptor 2; Notch 2; Neurogenic Locus Notch Homolog Protein 2; HN2; Notch (Drosophila) Homolog 2; Notch Homolog 2 (Drosophila); Notch Homolog 2; HJCYS; AGS2
UniProt Entry:   Q04721
NCBI Gene Entry:   4853
Molecular Weight:   110, 300 kDa
Clonality:   Rabbit polyclonal antibody
Species Reactivity:   Human
Applications:   IC
Recommended Dilution:   IC 1:500
Immunogen:   Recombinant fragment of human NOTCH2
Isotype:   Rabbit IgG 
Storage Buffer:   Supplied in PBS (pH 7.5) containing 50 µg/ml BSA, 50% glycerol, and 0.01% sodium azide  
Storage:   At –20°C
Background:   NOTCH2 gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene.
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