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Product Category: | Knockdown Validated Polyclonal Antibody |
Synonyms: | Poly(ADP-Ribose) Polymerase 1; ADP-Ribosyltransferase (NAD+; Poly (ADP-Ribose) Polymerase) ; ADP-Ribosyltransferase Diphtheria Toxin-Like 1; Poly (ADP-Ribose) Polymerase Family, Member 1; Protein Poly-ADP-Ribosyltransferase PARP1; DNA ADP-Ribosyltransferase PARP1;NAD(+) ADP-Ribosyltransferase 1; Poly [ADP-Ribose] Polymerase 1; Poly[ADP-Ribose] Synthase 1; EC 2.4.2.30;ADPRT 1; PARP-1; ADPRT; ARTD1 ; PPOL; ADP-Ribosyltransferase NAD(+); Poly(ADP-Ribosyl)Transferase;Poly(ADP-Ribose) Synthetase; EC 2.4.2.- ; PADPRT-1; EC 2.4.2;ADPRT1; PARP |
UniProt Entry: | P09874 |
NCBI Gene Entry: | 142 |
Molecular Weight: | 89, 116 kDa |
Clonality: | Rabbit polyclonal antibody |
Species Reactivity: | Human |
Applications: | WB/IC/F |
Recommended Dilution: | WB 1:1000 / IC 1:400 / F 1:200 |
Immunogen: | Recombinant fragment of human PARP1 |
Isotype: | Rabbit IgG |
Storage Buffer: | Supplied in PBS (pH 7.5) containing 50 µg/ml BSA, 50% glycerol, and 0.01% sodium azide |
Storage: | At –20°C |
Background: | PARP1 gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. |
Documents: | Please contact us to request the manual |