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Product Category: | Knockdown Validated Polyclonal Antibody |
Synonyms: | TSC Complex Subunit 2; Protein Phosphatase 1, Regulatory Subunit 160; Tuberous Sclerosis 2 Protein; Tuberin; TSC4;Tuberous Sclerosis 2; PPP1R160; LAM |
UniProt Entry: | P49815 |
NCBI Gene Entry: | 7249 |
Molecular Weight: | 200 kDa |
Clonality: | Rabbit polyclonal antibody |
Species Reactivity: | Human |
Applications: | WB/IC/F |
Recommended Dilution: | WB 1:1000 / IC 1:200 / F 1:500 |
Immunogen: | Recombinant fragment of human TSC2 |
Isotype: | Rabbit IgG |
Storage Buffer: | Supplied in PBS (pH 7.5) containing 50 µg/ml BSA, 50% glycerol, and 0.01% sodium azide |
Storage: | At –20°C |
Background: | Mutations in TSC2 gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. |
Documents: | Please contact us to request the manual |