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| Product Category: | Knockdown Validated Polyclonal Antibody |
| Synonyms: | ASH2 Like, Histone Lysine Methyltransferase Complex Subunit; Set1/Ash2 Histone Methyltransferase Complex Subunit ASH2; ASH2-Like Protein; ASH2L1; ASH2 Like Histone Lysine Methyltransferase Complex Subunit; Ash2 (Absent, Small, Or Homeotic)-Like (Drosophila); Ash2 (Absent, Small, Or Homeotic)-Like; ASH2L2; ASH2; Bre2 |
| UniProt Entry: | Q9UBL3 |
| NCBI Gene Entry: | 9070 |
| Molecular Weight: | 65, 80 kDa |
| Clonality: | Rabbit polyclonal antibody |
| Species Reactivity: | Human |
| Applications: | WB/IC |
| Recommended Dilution: | WB 1:1000/ IC 1:300 |
| Immunogen: | Recombinant fragment of human ASH2L |
| Isotype: | Rabbit IgG |
| Storage Buffer: | Supplied in PBS (pH 7.5) containing 50 µg/ml BSA, 50% glycerol, and 0.01% sodium azide |
| Storage: | At –20°C |
| Background: | The human ASH2L gene encodes a 628 amino acid protein known as ASH2L1, or isoform 1, which contains a nuclear localization signal and PHD finger motif, suggesting that the gene product functions as a transcription regulator. Alternative splicing results in a shorter isoform 2, designated ASH2L2, which is missing the first 94 amino acid residues found in ASH2L1. Human ASH2L proteins are 60% homologous to Drosophila ash2, which positively regulates expression of certain genes in early development, and contain similar, but not identical, domains, including a zinc finger motif. ASH2L is highly expressed in fetal liver, testis and leukemia cell lines with erythroid and megakaryocytic potential, such as K562, Hel and Dami. |
| Documents: | Request a manual/MSDS |
