ASH2L Polyclonal Antibody (20 μl)

ASH2L Polyclonal Antibody (20 μl)

Cat. #: 1734S
Availability: In Stock
Product Category:   Knockdown Validated Polyclonal Antibody
Synonyms:   ASH2 Like, Histone Lysine Methyltransferase Complex Subunit; Set1/Ash2 Histone Methyltransferase Complex Subunit ASH2; ASH2-Like Protein; ASH2L1; ASH2 Like Histone Lysine Methyltransferase Complex Subunit; Ash2 (Absent, Small, Or Homeotic)-Like (Drosophila); Ash2 (Absent, Small, Or Homeotic)-Like; ASH2L2; ASH2; Bre2
UniProt Entry:   Q9UBL3
NCBI Gene Entry:   9070
Molecular Weight:   65, 80 kDa
Clonality:   Rabbit polyclonal antibody
Species Reactivity:   Human
Applications:   WB/IC
Recommended Dilution:   WB 1:1000/ IC 1:300
Immunogen:   Recombinant fragment of human ASH2L
Isotype:   Rabbit IgG 
Storage Buffer:   Supplied in PBS (pH 7.5) containing 50 µg/ml BSA, 50% glycerol, and 0.01% sodium azide  
Storage:   At –20°C
Background:   The human ASH2L gene encodes a 628 amino acid protein known as ASH2L1, or isoform 1, which contains a nuclear localization signal and PHD finger motif, suggesting that the gene product functions as a transcription regulator. Alternative splicing results in a shorter isoform 2, designated ASH2L2, which is missing the first 94 amino acid residues found in ASH2L1. Human ASH2L proteins are 60% homologous to Drosophila ash2, which positively regulates expression of certain genes in early development, and contain similar, but not identical, domains, including a zinc finger motif. ASH2L is highly expressed in fetal liver, testis and leukemia cell lines with erythroid and megakaryocytic potential, such as K562, Hel and Dami.
Documents:   Request a manual/MSDS

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