Adenovirus SHH (200 µl)

Adenovirus SHH (200 µl)

Cat. #: M1108
Availability: In Stock
$685.00
-+
Product Category:   Human Adenovirus Type5 (dE1/E3) expressing Sonic Hedgehog Homolog (Drosophila) under CMV promoter.
Description:   Sonic Hedgehog Homolog (Drosophila), pre-made adenovirus, ready to ship and ready to use format.
Gene:   Sonic Hedgehog Homolog (Drosophila)
NCBI Acc. #:   BC111925
Gene ID:   6469
GI Number:   108752131
Fusion Tag:   C-terminus V5 epitope tag
Promoter:   CMV
Titer:   1x1010~1x1011 PFU/ml
Storage Buffer:   DMEM with 2.5% BSA, 2.5% glycerol
Background:   Sonic Hedgehog (SHH), which is expressed only during embryogenesis, is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the Sonic Hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved, the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. In addition, it is thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities.
Documents:   Request a manual/MSDS

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