CASP3 Monoclonal Antibody (20 μl)

CASP3 Monoclonal Antibody (20 μl)

Cat. #: 81173S
Availability: In Stock
Product Category:   Knockdown Validated Monoclonal Antibody
Synonyms:   Caspase 3; Caspase 3, Apoptosis-Related Cysteine Peptidase; Caspase 3, Apoptosis-Related Cysteine Protease; SREBP Cleavage Activity 1; Cysteine Protease CPP32; Protein Yama; EC; Caspase-3; Apopain; CASP-3; CPP-32; CPP32; SCA-1; PARP Cleavage Protease; Procaspase3; EC 3.4.22; CPP32B
UniProt Entry:   P42574 
NCBI Gene Entry:   836 
Molecular Weight:   17,19,35 kDa 
Clonality:   Rabbit monoclonal antibody 
Species Reactivity:   Human
Applications:   WB
Recommended Dilution:   WB 1:1000
Immunogen:   Recombinant fragment of human CASP3 
Isotype:   Rabbit IgG 
Storage Buffer:   Supplied in PBS (pH 7.5) containing 50 µg/ml BSA, 50% glycerol, and 0.01% sodium azide  
Storage:   At –20°C
Background:   CASP3 gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
Documents:   Request a manual/MSDS

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