CCND1 Polyclonal Antibody (20 μl)

CCND1 Polyclonal Antibody (20 μl)

Cat. #: 1151S
Availability: In Stock
Product Category:   Knockdown Validated Polyclonal Antibody
Synonyms:   Cyclin D1; B-Cell Lymphoma 1 Protein; G1/S-Specific Cyclin-D1; B-Cell CLL/Lymphoma 1; BCL-1 Oncogene; PRAD1 Oncogene; PRAD1; BCL1; Cyclin D1 (PRAD1: Parathyroid Adenomatosis1) ; Parathyroid Adenomatosis1; G1/S-Specific Cyclin D1; D11S287E; U21B31; BCL-1
UniProt Entry:   P24385 
NCBI Gene Entry:   595 
Molecular Weight:   36 kDa 
Clonality:   Rabbit polyclonal antibody
Species Reactivity:   Human
Applications:   WB
Recommended Dilution:   WB 1:1000
Immunogen:   Recombinant fragment of human CCND1 
Isotype:   Rabbit IgG 
Storage Buffer:   Supplied in PBS (pH 7.5) containing 50 µg/ml BSA, 50% glycerol, and 0.01% sodium azide  
Storage:   At –20°C
Background:   CCND1 protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
Documents:   Request a manual/MSDS

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