CCND2 Polyclonal Antibody (20 μl)

CCND2 Polyclonal Antibody (20 μl)

Cat. #: 1152S
Availability: In Stock
$119.00
-+
Product Category:   Knockdown Validated Polyclonal Antibody
Synonyms:   Cyclin D2; G1/S-Specific Cyclin-D2; G1/S-Specific Cyclin D2; KIAK0002; MPPH3
UniProt Entry:   P30279 
NCBI Gene Entry:   894 
Molecular Weight:   31 kDa 
Clonality:   Rabbit polyclonal antibody
Species Reactivity:   Human
Applications:   WB
Recommended Dilution:   WB 1:1000
Immunogen:   Recombinant fragment of human CCND2  
Isotype:   Rabbit IgG 
Storage Buffer:   Supplied in PBS (pH 7.5) containing 50 µg/ml BSA, 50% glycerol, and 0.01% sodium azide  
Storage:   At –20°C
Background:   CCND2 protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3).
Documents:   Request a manual/MSDS

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