EIF4EBP1 Polyclonal Antibody (20 μl)

Cat. #: 2361S
Availability: In Stock
Product Category:    Knockdown Validated Polyclonal Antibody
Synonyms:    Eukaryotic Translation Initiation Factor 4E Binding Protein 1;Phosphorylated Heat- And Acid-Stable Protein Regulated By Insulin 1; Eukaryotic Translation Initiation Factor 4E-Binding Protein 1; EIF4E-Binding Protein 1; 4E-BP1; PHAS-I; 4EBP1; BP-1
UniProt Entry:    Q13541
NCBI Gene Entry:    1978
Molecular Weight:    15-20 kDa
Clonality:    Rabbit polyclonal antibody
Species Reactivity:    Human
Applications:    WB/IC/F 
Recommended Dilution:    WB 1:1000 / IC 1:500 / F 1:300
Immunogen:    Recombinant fragment of human EIF4EBP1
Isotype:    Rabbit IgG 
Storage Buffer:    Supplied in PBS (pH 7.5) containing 50 µg/ml BSA, 50% glycerol, and 0.01% sodium azide  
Storage:    At –20°C
Background:    EIF4EBP1 gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
Documents:    Request a manual/MSDS

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