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| Product Category: | Knockdown Validated Polyclonal Antibody |
| Synonyms: | Eukaryotic Translation Initiation Factor 4E Binding Protein 1;Phosphorylated Heat- And Acid-Stable Protein Regulated By Insulin 1; Eukaryotic Translation Initiation Factor 4E-Binding Protein 1; EIF4E-Binding Protein 1; 4E-BP1; PHAS-I; 4EBP1; BP-1 |
| UniProt Entry: | Q13541 |
| NCBI Gene Entry: | 1978 |
| Molecular Weight: | 15-20 kDa |
| Clonality: | Rabbit polyclonal antibody |
| Species Reactivity: | Human |
| Applications: | WB/IC/F |
| Recommended Dilution: | WB 1:1000 / IC 1:500 / F 1:300 |
| Immunogen: | Recombinant fragment of human EIF4EBP1 |
| Isotype: | Rabbit IgG |
| Storage Buffer: | Supplied in PBS (pH 7.5) containing 50 µg/ml BSA, 50% glycerol, and 0.01% sodium azide |
| Storage: | At –20°C |
| Background: | EIF4EBP1 gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. |
| Documents: | Request a manual/MSDS |
