HIF1A Polyclonal Antibody (20 μl)  

Cat. #: 3321S
Availability: In Stock
Synonyms:   Hypoxia Inducible Factor 1 Subunit Alpha; Hypoxia Inducible Factor 1, Alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) ; Class E Basic Helix-Loop-Helix Protein 78; Basic-Helix-Loop-Helix-PAS Protein MOP1; Hypoxia-Inducible Factor 1-Alpha; PAS Domain-Containing Protein 8; Member Of PAS Protein 1; HIF-1-Alpha; BHLHe78; PASD8; MOP1; Hypoxia-Inducible Factor 1 Alpha Isoform I.3; Hypoxia Inducible Factor 1 Alpha Subunit; Hypoxia-Inducible Factor1alpha; Member Of PAS Superfamily 1; ARNT Interacting Protein; ARNT-Interacting Protein; HIF-1alpha; HIF1-ALPHA; HIF1-Alpha; BHLHE78; HIF-1A; HIF1
UniProt Entry:   Q16665
NCBI Gene Entry:   3091
Molecular Weight:   120 kDa
Clonality:   Rabbit polyclonal antibody
Validated:   Knockdown
Species Reactivity:   Human
Applications:   WB/IC/F 
Recommended Dilution:   WB 1:1000 / IC 1:300 / F 1:100
Immunogen:   Recombinant fragment of human HIF1A
Isotype:   Rabbit IgG 
Storage Buffer:   Supplied in PBS (pH 7.5) containing 50 µg/ml BSA, 50% glycerol, and 0.01% sodium azide  
Storage:   At –20°C
Background:   HIF1A gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease.
Documents:   Request a manual/MSDS

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