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| Product Name: | CTF1 Protein (Fc Tag),Human |
| Synonym: | Cardiotrophin-1,CT-1 |
| Background: | Cardiotrophin-1 (CT-1) is a member of the cytokine family which also includes IL-6, IL-11, l LIF, CNTF, OSM. CT-1 has since been shown to be a pleiotrophic cytokine with overlapping actions with other IL-6 family members on a variety of cell types. Biologically active human CT-1 is synthesized as a 201 amino acid polypeptide lacking a hydrophobic N-terminal secretion signal sequence. Recombinant Human CT-1 is a 21.1 kDa protein consisting of 200 amino acid residues. |
| Protein Construction: | A DNA sequence encoding the human CTF1(NP_001321.1)(Ser2-Ala201) was expressed with the fused Fc region of human IgG1 at the N-terminus. |
| Molecule Mass: | The recombinant human CTF1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 460 amino acids and has a predicted molecular mass of 49.5 kDa. The apparent molecular mass of the protein is approximately 54 and 37 kDa in SDS-PAGE under reducing conditions due to glycosylation. |
| Species: | Human |
| Expressed Host: | Human Cells |
| Purity: | > 85 % as determined by SDS-PAGE |
| Bio-Activity: | Measured in a cell proliferation assay using TF-1 human erythroleukemic cells.The ED50 for this effect is typically 0.015-0.06 μg/mL. |
| Endotoxin: | < 1.0 EU per μg of the protein as determined by the LAL method |
| Stability: | Samples are stable for up to twelve months from date of receipt at -70℃ |
| Storage: | Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
