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| Product Category: | Knockdown Validated Polyclonal Antibody |
| Synonyms: | Ring Finger Protein 2; Huntingtin-Interacting Protein 2-Interacting Protein 3; RING-Type E3 Ubiquitin Transferase RING2; E3 Ubiquitin-Protein Ligase RING2; HIP2-Interacting Protein 3; RING Finger Protein BAP-1; RING Finger Protein 1B;Protein DinG; RING1B; HIPI3; BAP1; DING; RING Finger Protein 2; EC 2.3.2.27; EC 6.3.2; RING1b; BAP-1; RING2 |
| UniProt Entry: | Q99496 |
| NCBI Gene Entry: | 6045 |
| Molecular Weight: | 41 kDa |
| Clonality: | Rabbit polyclonal antibody |
| Species Reactivity: | Human |
| Applications: | IC |
| Recommended Dilution: | IC 1:200 |
| Immunogen: | Recombinant fragment of human RNF2 |
| Isotype: | Rabbit IgG |
| Storage Buffer: | Supplied in PBS (pH 7.5) containing 50 µg/ml BSA, 50% glycerol, and 0.01% sodium azide |
| Storage: | At –20°C |
| Background: | Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. RNF2 protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity. |
| Documents: | Request a manual/MSDS |
