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ABflo® 488 Rabbit anti-Human CD263/TRAIL-R3 mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 488. Ex:491nm. Em:516nm. |
| Gene Name: | TNF receptor superfamily member 10c |
| Gene Symbol: | TNFRSF10C |
| Synonyms: | LIT; DCR1; TRID; CD263; TRAILR3; TRAIL-R3; DCR1-TNFR |
| Gene ID: | 8794 |
| UniProt ID: | O14798 |
| Clone ID: | 9K5T10 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-235 of human CD263/TRAIL-R3(NP_003832.3). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-TNFRSF10C Antibody |
Background
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.
Images
 | Flow cytometry: 1×10^6 K-562 cells (Low Expression,left) and BEWO cells (right) were surface-stained with ABflo® 488 Rabbit anti-Human CD263/TRAIL-R3 mAb (A24795,5 μl/Test,orange line) or ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 BEWO cells were surface-stained with ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,left) or ABflo® 488 Rabbit anti-Human CD263/TRAIL-R3 mAb (A24795,5 μl/Test,right). |
 | Flow cytometry: 1×10^6 Human peripheral blood granulocytes were surface-stained with ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,left) or ABflo® 488 Rabbit anti-Human CD263/TRAIL-R3 mAb (A24795,5 μl/Test,right). |
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