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ABflo® 488 Rabbit anti-Human CD87/PLAUR mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 488. Ex:491nm. Em:516nm. |
| Gene Name: | plasminogen activator, urokinase receptor |
| Gene Symbol: | PLAUR |
| Synonyms: | CD87; UPAR; URKR; U-PAR |
| Gene ID: | 5329 |
| UniProt ID: | Q03405 |
| Clone ID: | 8J6I3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-303 of human CD87/PLAUR (NP_002650.1). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-PLAUR Antibody |
Background
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined.
Images
 | Flow cytometry: 1×10^6 Daudi cells(negative control,left) and U-87MG cells (right) were surface-stained with ABflo® 488 Rabbit anti-Human CD87/PLAUR mAb(A24230,5 μl/Test,orange line) or ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,blue line).Non-fluorescently stained cells was used as blank control (red line). |
 | Flow cytometry:1×10^6 U-87MG cells were surface-stained with ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,left) or ABflo® 488 Rabbit anti-Human CD87/PLAUR mAb(A24230,5 μl/Test,right). |
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