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ABflo® 488 Rabbit anti-Human LILRB4/CD85k/ILT3 mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 488. Ex:491nm. Em:516nm. |
| Gene Name: | leukocyte immunoglobulin like receptor B4 |
| Gene Symbol: | LILRB4 |
| Synonyms: | B4; ILT3; LIR5; CD85K; ILT-3; LIR-5 |
| Gene ID: | 11006 |
| UniProt ID: | Q8NHJ6 |
| Clone ID: | 2V10W8 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-259 of human LILRB4/CD85k/ILT3 (NP_001265355.2). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.01 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-LILRB4 Antibody |
Background
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
Images
 | Flow cytometry:1×10^6 293F cells(negative control,left) and THP-1 cells (right) were surface-stained with ABflo® 488 Rabbit anti-Human LILRB4/CD85k/ILT3 mAb(A23358,5 μl/Test,orange line) or ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,blue line).Non-fluorescently stained cells was used as blank control (red line). |
 | Flow cytometry:1×10^6 THP-1 cells were surface-stained with ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,left) or ABflo® 488 Rabbit anti-Human LILRB4/CD85k/ILT3 mAb(A23358,5 μl/Test,right). |
 | Flow cytometry:1×10^6 Human PBMC were surface-stained with ABflo® 488 Rabbit anti-Human LILRB4/CD85k/ILT3 mAb(A23358,5 μl/Test,orange line) or ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry:1×10^6 Human PBMC were surface-stained with ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,left) or ABflo® 488 Rabbit anti-Human LILRB4/CD85k/ILT3 mAb(A23358,5 μl/Test,right). |
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