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ABflo® 488 Rabbit anti-Human/Mouse PDGFRα/CD140a mAb (100 T)
| Reactivity: | Human,Mouse |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 488. Ex:491nm. Em:516nm. |
| Gene Name: | platelet derived growth factor receptor alpha |
| Gene Symbol: | PDGFRA |
| Synonyms: | CD140A; PDGFR2; PDGFR-2 |
| Gene ID: | 5156 |
| UniProt ID: | P16234 |
| Clone ID: | 1L6L6 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-524 of human PDGFRα (NP_006197.1). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-PDGFRA Antibody |
Background
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.
Images
 | Flow cytometry:1×10^6 HeLa cells (negative control,Left) and U-138 MG cells (Right) were surface-stained with ABflo® 488 Rabbit anti-Mouse PDGFRα/CD140a mAb (A22689,5 μl/Test,orange line) or ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 NIH/3T3 cells were surface-stained with ABflo® 488 Rabbit anti-Mouse PDGFRα/CD140a mAb (A22689,5 μl/Test,orange line) or ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,blue line).Non-fluorescently stained NIH/3T3 cells were used as blank control (red line). |
 | Flow cytometry:1×10^6 U-138 MG cells were surface-stained with ABflo™ 488 Rabbit IgG isotype control (A22069,5 μl/Test,left) or ABflo™ 488 Rabbit anti-Human/Mouse PDGFRα/CD140a mAb (A22689,5 μl/Test,right). |
 | Flow cytometry:1×10^6 NIH/3T3 cells were surface-stained with ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,left) or ABflo® 488 Rabbit anti-Mouse PDGFRα/CD140a mAb (A22689,5 μl/Test,right). |
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