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ABflo® 488 Rabbit anti-Human Nectin-4 mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 488. Ex:491nm. Em:516nm. |
| Gene Name: | nectin cell adhesion molecule 4 |
| Gene Symbol: | NECTIN4 |
| Synonyms: | LNIR; PRR4; EDSS1; PVRL4; nectin-4 |
| Gene ID: | 81607 |
| UniProt ID: | Q96NY8 |
| Clone ID: | 1M6S10 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 32-146 of human Nectin-4 (NP_112178.2). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-NECTIN4 antibody |
Background
Nectin-4/ poliovirus Receptor-like 4 (PVRL4) is a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily that promotes intercellular adhesion by acting as a major component of adhesion junctions. The extracellular domain of Nectin-4 consists of one Ig variable region (V) and two Ig constant regions (C), which mediate binding to measles virus and adjacent cells through trans-heterophile interactions with Nectin-1. Unlike other members of the connectin family, which are widely expressed in adult tissues, human Nectin-4 expression is largely limited to the blastoderm. Studies have shown that Nectin-4 is overexpressed in cells from a variety of human solid tumors, including pancreatic, breast, lung, and ovarian cancers. The expression pattern of Nectin-4 in normal tissues is limited, so NECTIN-4 can be used as a novel therapeutic target for various human tumors.
Images
 | Flow cytometry: 1×10^6 HAP1 cells (negative control,left) and T-47D cells (right) were surface-stained with ABflo® 488 Rabbit anti-Human Nectin-4 mAb (A25192,5 μl/Test,orange line) or ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 T-47D cells were surface-stained with ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,left) or ABflo® 488 Rabbit anti-Human Nectin-4 mAb (A25192,5 μl/Test,right). |
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