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ABflo® 488 Rabbit anti-Human Syk mAb (100 T)
| Reactivity: | Human |
| Applications: | FC (intra) |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 488. Ex:491nm. Em:516nm. |
| Gene Name: | spleen associated tyrosine kinase |
| Gene Symbol: | SYK |
| Synonyms: | IMD82; p72-Syk |
| Gene ID: | 6850 |
| UniProt ID: | P43405 |
| Clone ID: | 8G10B0 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 251-350 of human Syk (NP_003168.2). |
| Dilution: | FC (intra),5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-SYK Antibody |
Background
This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Images
 | Flow cytometry: 1×10^6 Human PBMC were surface-stained with APC anti-human CD19 Antibody (5 μl/Test) followed by intracellular staining with ABflo® 488 Rabbit anti-Human Syk mAb (A25738,5 μl/Test,left) or ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,right). |
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