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ABflo® 488 Rabbit anti-Mouse IgM mAb (100 T)
| Reactivity: | Mouse |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 488. Ex:491nm. Em:516nm. |
| Gene Symbol: | Immunoglobulin heavy constant mu |
| Synonyms: | Igm; muH; Igh6; Igh-6; Igh-M |
| UniProt ID: | P01872 |
| Clone ID: | 9A4I7 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 105-454 of mouse IgM (P01872). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual- |
Background
Enables several functions, including antigen binding activity; identical protein binding activity; and immunoglobulin receptor binding activity. Acts upstream of or within several processes, including early endosome to late endosome transport; immunoglobulin mediated immune response; and positive regulation of B cell proliferation. Located in external side of plasma membrane; extracellular space; and perinuclear region of cytoplasm. Part of B cell receptor complex and immunoglobulin complex, circulating. Is expressed in several structures, including brain; hemolymphoid system; and liver. Used to study non-Hodgkin lymphoma and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in agammaglobulinemia. Orthologous to human IGHM (immunoglobulin heavy constant mu).
Images
 | Flow cytometry: 1×10^6 NIH/3T3 cells (negative control,left) and C57/BL6 splenocytes (right) were surface-stained with ABflo® 488 Rabbit anti-Mouse IgM mAb (A23114,5 μl/Test,orange line) or ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 C57/BL6 splenocytes were surface-stained with ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,left) or ABflo® 488 Rabbit anti-Mouse IgM mAb (A23114,5 μl/Test,right). |
 | Flow cytometry: 1×10^6 NIH/3T3 cells (negative control,left) and Mouse PBMC (right) were surface-stained with ABflo® 488 Rabbit anti-Mouse IgM mAb (A23114,5 μl/Test,orange line) or ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 Mouse PBMC were surface-stained with ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,left) or ABflo® 488 Rabbit anti-Mouse IgM mAb (A23114,5 μl/Test,right). |
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