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ABflo® 488 Rat anti-Mouse MHC Class II (I-A/I-E) mAb (100 T)
| Reactivity: | Mouse |
| Applications: | FC |
| Host Species: | Rat |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 488. Ex:491nm. Em:516nm. |
| Gene Name: | histocompatibility 2, class II antigen A, alpha |
| Gene Symbol: | H2-Aa |
| Synonyms: | Ia1; H2Aa; Ia-1; H-2Aa; Aalpha; IAalpha; I-Aalpha |
| Gene ID: | 14969/14961/381091/14960 |
| UniProt ID: | P18468/P06342/Q3U060/P14435 |
| Clone ID: | 5G7Y7 |
| Immunogen: | Recombinant protein of mouse MHC Class II (I-A/I-E). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/mL |
| Buffer: | PBS with 0.03% proclin300,pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-H2-Aa antibody |
Background
Predicted to enable several functions, including MHC class II receptor activity; peptide antigen binding activity; and signaling receptor binding activity. Involved in response to interferon-gamma. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II. Predicted to be located in external side of plasma membrane and immunological synapse. Predicted to be part of MHC class II protein complex. Predicted to be active in late endosome membrane and lysosomal membrane. Is expressed in lung. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); bacterial infectious disease (multiple); eye disease (multiple); and sarcoidosis (multiple). Orthologous to human HLA-DRB1 (major histocompatibility complex, class II, DR beta 1) and HLA-DRB5 (major histocompatibility complex, class II, DR beta 5).
Images
 | Flow cytometry: 1×10^6 Neuro-2a cells (negative control,left) and C57BL/6 mouse Splenocytes (right) were surface-stained with ABflo® 488 Rat anti-Mouse MHC Class II (I-A/I-E) mAb (A25481,5 μl/Test,orange line) or ABflo® 488 Rat IgG isotype control (2 μg/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 C57BL/6 mouse Splenocytes were surface-stained with ABflo® 488 Rat IgG isotype control (2 μg/Test,left) or ABflo® 488 Rat anti-Mouse MHC Class II (I-A/I-E) mAb (A25481,5 μl/Test,right). |
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