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ABflo® 594 Rabbit anti-Human IFN-alpha/beta R2 mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 594. Ex:588nm. Em:604nm. |
| Gene Name: | interferon alpha and beta receptor subunit 2 |
| Gene Symbol: | IFNAR2 |
| Synonyms: | IFN-R; IMD45; IFNABR; IFNARB; IFN-R-2; IFN-alpha-REC |
| Gene ID: | 3455 |
| UniProt ID: | P48551 |
| Clone ID: | 5H7X8 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-237 of human IFN-alpha/beta R2(NP_008896.2). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-IFNAR2 Antibody |
Background
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family. Mutations in this gene are associated with Immunodeficiency 45.
Images
 | Flow cytometry: 1×10^6 T-47D cells (Low Expression,left) and U266 cells (right) were surface-stained with ABflo® 594 Rabbit anti-Human IFN-alpha/beta R2 mAb (A25114,5 μl/Test,orange line) or ABflo® 594 Rabbit IgG isotype control (A23821,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 U266 cells were surface-stained with ABflo® 594 Rabbit IgG isotype control (A23821,5 μl/Test,left) or ABflo® 594 Rabbit anti-Human IFN-alpha/beta R2 mAb (A25114,5 μl/Test,right). |
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