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ABflo® 594 Rabbit anti-Human LIFR/CD118 mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 594. Ex:588nm. Em:604nm. |
| Gene Name: | LIF receptor subunit alpha |
| Gene Symbol: | LIFR |
| Synonyms: | SWS; SJS2; STWS; CD118; LIF-R |
| Gene ID: | 3977 |
| UniProt ID: | P42702 |
| Clone ID: | 8D7P8 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 45-833 of human LIFR/CD118 (NP_002301.1). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-LIFR Antibody |
Background
This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding two different isoforms have been found for this gene.
Images
 | Flow cytometry: 1×10^6 REH cells (negative control,left) and HeLa cells (right) were surface-stained with ABflo® 594 Rabbit anti-Human LIFR/CD118 mAb (A25078,5 μl/test,orange line) or ABflo® 594 Rabbit IgG isotype control (A23821,5 μl/test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 HeLa cells were surface-stained with ABflo® 594 Rabbit IgG isotype control (A23821,5 μl/test,left) or ABflo® 594 Rabbit anti-Human LIFR/CD118 mAb (A25078,5 μl/test,right). |
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