Reactivity: | Human |
Applications: | FC |
Host Species: | Rabbit |
Isotype: | IgG |
Clonality: | Monoclonal Antibody |
Conjugation: | ABflo® 594. Ex:588nm. Em:604nm. |
Gene Name: | MHC class I polypeptide-related sequence B |
Gene Symbol: | MICB |
Synonyms: | PERB11.2 |
Gene ID: | 100507436/4277 |
UniProt ID: | Q29983/Q29980 |
Clone ID: | 10N7J4 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-298 of human MICB (NP_005922.2). |
Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
Purification Method: | Affinity purification |
Concentration: | 0.04 mg/mL |
Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
Documents: | Manual-MICB antibody |
Background
This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants.
Images
![]() | Flow cytometry: 1×10^6 SH-SY5Y cells (negative control,left) and K-562 cells (right) were surface-stained with ABflo® 594 Rabbit anti-Human MICA/MICB mAb (A25278,5 μl/Test,orange line) or ABflo® 594 Rabbit IgG isotype control (A23821,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
![]() | Flow cytometry: 1×10^6 K-562 cells were surface-stained with ABflo® 594 Rabbit IgG isotype control (A23821,5 μl/Test,left) or ABflo® 594 Rabbit anti-Human MICA/MICB mAb (A25278,5 μl/Test,right). |
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