ABflo® 594 Rabbit anti-Mouse CD130/gp130 mAb (100 T)

Brand: Abclonal
Cat. #: A24985
Availability: In Stock

$290.00

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Description

Reactivity:	Mouse
Applications:	FC
Host Species:	Rabbit
Isotype:	IgG
Clonality:	Monoclonal Antibody
Conjugation:	ABflo® 594. Ex:588nm. Em:604nm.
Gene Name:	interleukin 6 signal transducer
Gene Symbol:	Il6st
Synonyms:	CD130; gp130; D13Ertd699e; 5133400A03Rik
Gene ID:	16195
UniProt ID:	Q00560
Clone ID:	5A2M8
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 23-617 of mouse CD130/gp130 (NP_034690.3).
Dilution:	FC,5 μl per 10^6 cells in 100 μl volume
Purification Method:	Affinity purification
Concentration:	0.04 mg/mL
Buffer:	PBS with 0.03% proclin300,0.2% BSA, pH7.3.
Storage:	Store at -20°C. Avoid freeze / thaw cycles.
Documents:	Manual-Il6st antibody

Background

Contributes to interleukin-11 binding activity and interleukin-11 receptor activity. Involved in interleukin-6-mediated signaling pathway; intestinal epithelial cell development; and positive regulation of Notch signaling pathway. Acts upstream of or within several processes, including glycogen metabolic process; positive regulation of astrocyte differentiation; and regulation of Notch signaling pathway. Located in dendrite; external side of plasma membrane; and neuronal cell body. Is expressed in several structures, including alimentary system; brain; early conceptus; immune system; and reproductive system. Used to study rheumatoid arthritis and stomach cancer. Human ortholog(s) of this gene implicated in arteriosclerosis; hyper IgE recurrent infection syndrome 4; and hyperandrogenism. Orthologous to human IL6ST (interleukin 6 cytokine family signal transducer).

Images

	Flow cytometry: 1×10^6 Neuro-2a cells (Low Expression,left) and NIH/3T3 cells (right) were surface-stained with ABflo® 594 Rabbit anti-Mouse CD130/gp130 mAb (A24985,5 μl/Test,orange line) or ABflo® 594 Rabbit IgG isotype control (A23821,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line).
	Flow cytometry: 1×10^6 NIH/3T3 cells were surface-stained with ABflo® 594 Rabbit IgG isotype control (A23821,5 μl/Test,left) or ABflo® 594 Rabbit anti-Mouse CD130/gp130 mAb (A24985,5 μl/Test,right).