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ABflo® 594 Rabbit anti-Mouse CD274/PD-L1 mAb (100 T)
| Reactivity: | Mouse |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 594. Ex:588nm. Em:604nm. |
| Gene Name: | CD274 antigen |
| Gene Symbol: | Cd274 |
| Synonyms: | B7h1; Pdl1; Pdcd1l1; Pdcd1lg1; A530045L16Rik |
| Gene ID: | 60533 |
| UniProt ID: | Q9EP73 |
| Clone ID: | 10G9T3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-235 of mouse CD274/PD-L1(NP_068693.1). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.01 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-Cd274 antibody |
Background
The protein encoded by this gene is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Mice deficient for this gene display a variety of phenotypes including decreased allogeneic fetal survival rates and severe experimental autoimmune encephalomyelitis.
Images
 | Flow cytometry: 1×10^6 C2C12 cells (Low Expression,left) and A20 cells (right) were surface-stained with ABflo® 594 Rabbit anti-Mouse CD274/PD-L1 mAb (A24570,5 μl/Test,orange line) or ABflo® 594 Rabbit IgG isotype control (A23821,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 A20 cells were surface-stained with ABflo® 594 Rabbit IgG isotype control (A23821,5 μl/Test,left) or ABflo® 594 Rabbit anti-Mouse CD274/PD-L1 mAb (A24570,5 μl/Test,right). |
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