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Anti-5HT1A Receptor Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | 5-hydroxytryptamine receptor 1A |
Synonyms: | 5-HT1A, ADRB2RL1, ADRBRL1, HTR1A |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse 5HT1A Receptor |
Uniprot ID: | Q64264 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane, Cell projection |
Product Usage Information
IHC/IF | Human, Mouse, Rat | 1: 1000-1: 2000 | brain, kidney |
Background
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
Images
| Immunohistochemistry analysis of paraffin embedded mouse brain using 5HT1A Receptor (GB114285) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded mouse kidney using 5HT1A Receptor (GB114285) at dilution of 1: 1000 |
| Immunofluorescence analysis of paraffin embedded mouse kidney using 5HT1A Receptor (GB114285) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |