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ABflo® 647 Rabbit anti-Human CD141/Thrombomodulin mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 647. Ex:648nm. Em:664nm. |
| Gene Name: | thrombomodulin |
| Gene Symbol: | THBD |
| Synonyms: | TM; THRM; AHUS6; BDCA3; CD141; BDCA-3; THPH12 |
| Gene ID: | 7056 |
| UniProt ID: | P07204 |
| Clone ID: | 5I4U7 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-515 of human CD141/Thrombomodulin (NP_000352.1). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-THBD Antibody |
Background
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia.
Images
 | Flow cytometry:1×10^6 Jurkat cells (negative control,left) and THP-1 cells (right) were surface-stained with ABflo® 647 Rabbit anti-Human CD141/Thrombomodulin mAb(A22155,5 μl/Test,orange line) or ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry:1×10^6 Human PBMC were surface-stained with ABflo® 647 Rabbit anti-Human CD141/Thrombomodulin mAb(A22155,5 μl/Test,orange line) or ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,blue line).Non-fluorescently stained Human PBMC was used as blank control (red line). |
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