ABflo® 647 Rabbit anti-Human CD85j/ILT2 mAb (100 T)

Background

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

Images

	Flow cytometry: 1×10^6 K-562 cells(negative control,left) and Daudi cells(right) were surface-stained with ABflo® 647 Rabbit anti-Human CD85j/ILT2 mAb(A23588,5 μl/Test,orange line) or ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,blue line).Non-fluorescently stained cells was used as blank control (red line).
	Flow cytometry:1×10^6 Daudi cells were surface-stained with ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,left) or ABflo® 647 Rabbit anti-Human CD85j/ILT2 mAb(A23588,5 μl/Test,right).

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