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ABflo® 647 Rabbit anti-Human CD86 mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 647. Ex:648nm. Em:664nm. |
| Gene Name: | CD86 molecule |
| Gene Symbol: | CD86 |
| Synonyms: | B70; B7-2; B7.2; LAB72; CD28LG2 |
| Gene ID: | 942 |
| UniProt ID: | P42081 |
| Clone ID: | 3Y7P3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-241 of human CD86 (NP_787058.5). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.02 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-CD86 Antibody |
Background
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.
Images
 | Flow cytometry:1×10^6 K-562 cells (negative control,left) and Raji cells (right) were surface-stained with ABflo® 647 Rabbit anti-Human CD86 mAb(A21941,5 μl/Test,orange line) or ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
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