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ABflo® 647 Rabbit anti-Human PU.1/SPI1 mAb (100 T)
| Reactivity: | Human |
| Applications: | FC (intra) |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 647. Ex:648nm. Em:664nm. |
| Gene Name: | Spi-1 proto-oncogene |
| Gene Symbol: | SPI1 |
| Synonyms: | OF; PU.1; AGM10; SFPI1; SPI-1; SPI-A |
| Gene ID: | 6688 |
| UniProt ID: | P17947 |
| Clone ID: | 1E3W2 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PU.1/SPI1 (NP_003111.2). |
| Dilution: | FC (intra),5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-SPI1 Antibody |
Background
This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene.
Images
 | Flow cytometry: 1×10^6 HAP1 cells (negative control,left) and THP-1 cells (right) were intracellularly-stained with ABflo® 647 Rabbit anti-Human PU.1/SPI1 mAb (A24634,5 μl/Test,orange line) or ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 THP-1 cells were intracellularly-stained with ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,left) or ABflo® 647 Rabbit anti-Human PU.1/SPI1 mAb (A24634,5 μl/Test,right). |
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