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ABflo® 647 Rabbit anti-Human ROR1 mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 647. Ex:648nm. Em:664nm. |
| Gene Name: | receptor tyrosine kinase like orphan receptor 1 |
| Gene Symbol: | ROR1 |
| Synonyms: | NTRKR1; dJ537F10.1 |
| Gene ID: | 4919 |
| UniProt ID: | Q01973 |
| Clone ID: | 9A1U4 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-403 of Human ROR1 (NP_005003.2). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.01 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-ROR1 Antibody |
Background
This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
Images
 | Flow cytometry: 1×10^6 HEL cells (negative control,left) and MDA-MB-231 cells (right) were surface-stained with ABflo® 647 Rabbit anti-Human ROR1 mAb (A24901,5 μl/Test,orange line) or ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 MDA-MB-231 cells were surface-stained with ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,left) or ABflo® 647 Rabbit anti-Human ROR1 mAb (A24901,5 μl/Test,right). |
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