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ABflo® 647 Rabbit anti-Human TIM-3/HAVCR2 mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 647. Ex:648nm. Em:664nm. |
| Gene Name: | hepatitis A virus cellular receptor 2 |
| Gene Symbol: | HAVCR2 |
| Synonyms: | TIM3; CD366; KIM-3; SPTCL; TIMD3; Tim-3; TIMD-3; HAVcr-2 |
| Gene ID: | 84868 |
| UniProt ID: | Q8TDQ0 |
| Clone ID: | 6R5B8 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-200 of human TIM-3/HAVCR2 (NP_116171.3). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-HAVCR2 antibody |
Background
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
Images
 | Flow cytometry: 1×10^6 MCF7 cells (negative control,left) and Daudi cells (right) were surface-stained with ABflo® 647 Rabbit anti-Human TIM-3/HAVCR2 mAb (A22489,5 μl/Test,orange line) or ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,blue line). Non-fluorescently stained cells was used as blank control (red line). |
 | Flow cytometry: 1×10^6 Daudi cells were surface-stained with ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,left) or ABflo® 647 Rabbit anti-Human TIM-3/HAVCR2 mAb (A22489,5 μl/Test,right). |
 | Flow cytometry: 1×10^6 Human PBMC were surface-stained with ABflo® 647 Rabbit anti-Human TIM-3/HAVCR2 mAb (A22489,5 μl/Test,orange line) or ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,blue line). Non-fluorescently stained Human PBMC was used as blank control (red line). |
 | Flow cytometry: 1×10^6 Human PBMC cells were surface-stained with ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,left) or ABflo® 647 Rabbit anti-Human TIM-3/HAVCR2 mAb (A22489,5 μl/Test,right). |
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