ABflo® 647 Rabbit anti-Mouse CD209b/DC-SIGNR1 mAb (100 T)

ABflo® 647 Rabbit anti-Mouse CD209b/DC-SIGNR1 mAb (100 T)

Brand: Abclonal
Cat. #: A26548
Availability: In Stock
$328.00
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Reactivity: Mouse    
Applications: FC    
Host Species: Rabbit    
Isotype: IgG    
Clonality: Monoclonal Antibody    
Conjugation: ABflo® 647. Ex:648nm. Em:664nm.
Gene Name: CD209b antigen
Gene Symbol: Cd209b
Synonyms: OtB7; SIGNR1; mSIGNR1; DC-SIGNR1; 1810030I22Rik
Gene ID: 69165
UniProt ID: Q8CJ91
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 76-325 of mouse CD209b/DC-SIGNR1 (NP_081248.4).
Dilution: FC,5 μl per 10^6 cells in 100 μl volume
Purification Method: Affinity purification
Concentration: 0.04 mg/ml
Buffer: PBS with 0.09% Sodium azide,0.2% BSA, pH7.3.
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Documents: Manual-Cd209b antibody




Background

CD209B, also known as SIGN-R1, is a mouse C-type lectin receptor predominantly expressed on macrophages in the spleen marginal zone and lymph nodes medulla. CD209B is a mouse homolog of human CD209/DC-SIGN and is involved in innate immune response. CD209B mediates the recognition and uptake of pathogen products, such as lipopolysaccharides (LPS), pneumococcal polysaccharides, and dextrans. CD209B has been demonstrated to facilitate the clearance of encapsulated pneumococcus by directly binding to C1q and activating complement through an immunoglobulin independent pathway.




Images

Cd209b antibodyFlow cytometry: 1×10^6 C57BL/6 mouse splenocytes were surface-stained with ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,left) or ABflo® 647 Rabbit anti-Mouse CD209b/DC-SIGNR1 mAb (A26548,5 μl/Test,right).



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