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ABflo® 647 Rabbit anti-Mouse CD209b/DC-SIGNR1 mAb (100 T)
| Reactivity: | Mouse |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 647. Ex:648nm. Em:664nm. |
| Gene Name: | CD209b antigen |
| Gene Symbol: | Cd209b |
| Synonyms: | OtB7; SIGNR1; mSIGNR1; DC-SIGNR1; 1810030I22Rik |
| Gene ID: | 69165 |
| UniProt ID: | Q8CJ91 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 76-325 of mouse CD209b/DC-SIGNR1 (NP_081248.4). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/ml |
| Buffer: | PBS with 0.09% Sodium azide,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-Cd209b antibody |
Background
CD209B, also known as SIGN-R1, is a mouse C-type lectin receptor predominantly expressed on macrophages in the spleen marginal zone and lymph nodes medulla. CD209B is a mouse homolog of human CD209/DC-SIGN and is involved in innate immune response. CD209B mediates the recognition and uptake of pathogen products, such as lipopolysaccharides (LPS), pneumococcal polysaccharides, and dextrans. CD209B has been demonstrated to facilitate the clearance of encapsulated pneumococcus by directly binding to C1q and activating complement through an immunoglobulin independent pathway.
Images
 | Flow cytometry: 1×10^6 C57BL/6 mouse splenocytes were surface-stained with ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,left) or ABflo® 647 Rabbit anti-Mouse CD209b/DC-SIGNR1 mAb (A26548,5 μl/Test,right). |
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