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Anti-alpha smooth muscle Actin Rabbit pAb (100 μl)
| Reactivity: | Human, Mouse, Rat |
| Applications: | WB, IHC/IF, IEM |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | actin alpha 2, smooth muscle |
| Gene Symbol: | ACTA2 |
| Synonyms: | ACTSA; SMDYS |
| Gene ID: | 59 |
| Uniprot ID: | P62736, P62737, P62738 |
| Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse α smooth muscle actin |
| Isotype: | IgG |
| Purity: | Affinity purification |
| Subcellular location: | Cytoplasm |
| Documents: | Manual-ACTA2 Antibody |
Product Usage Information
| Applications | Species | Dilution | Positive Sample |
| WB | Human, Mouse, Rat | 1: 1000-1: 2000 | heart, liver |
| IHC/IF | Human, Mouse, Rat | 1: 300-1: 1000 | breast cancer, heart, liver, lung, lung cancer, brain, stomach |
| IEM | Mouse | 1: 50 | aorta |
Background
The gene ACTA2 encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a smooth muscle actin that is involved in vascular contractility and blood pressure homeostasis. Mutations in this gene cause a variety of vascular diseases, such as thoracic aortic disease, coronary artery disease, stroke, and Moyamoya disease, as well as multisystemic smooth muscle dysfunction syndrome.
Images
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Western blot analysis of alpha smooth muscle Actin (GB111364) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin-embedded human lung cancer using Actin (GB111364) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin-embedded mouse heart using Actin (GB111364) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin-embedded mouse lung using Actin (GB111364) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin-embedded rat lung using Actin (GB111364) at dilution of 1: 1000 |
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Immunofluorescent analysis of paraformaldehyde-fixed human breast cancer using Actin (GB111364) at dilution of 1: 300 |
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Immunofluorescent analysis of paraformaldehyde-fixed mouse lung using Actin (GB111364) at dilution of 1: 300 |
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Immunofluorescent analysis of paraformaldehyde-fixed rat heart using Actin (GB111364) at dilution of 1: 300 |
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Immunofluorescent analysis of paraformaldehyde-fixed rat liver using Actin (GB111364) at dilution of 1: 300 |
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Immunofluorescent analysis of paraformaldehyde-fixed human para-cancer lung using COLIII (GB11629) (green) + Collagen I (GB11022-3) (red) + Actin (GB111364) (yellow) + CD31 (GB12064) (orange) at dilution of 1: 300 |
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Immunofluorescent analysis of paraformaldehyde-fixed human lung cancer using Actin(GB111364) (green) + CD31(GB12064) (spred) + CD3(GB11014) (pink) at dilution of 1: 300 |
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Immunoelectron microscopy analysis of LR white resin-embedded mouse aorta using Actin (GB111364) at dilution of 1: 50. A goat anti-rabbit antibody preabsorbed with 10nm colloidal gold was used as the secondary antibody, at dilution of 1: 50 |
Storage
Storage |
Store at -20 °C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
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