APC Rabbit anti-Human Glypican 3 (GPC3) mAb (100 T)

APC Rabbit anti-Human Glypican 3 (GPC3) mAb (100 T)

Brand: Abclonal
Cat. #: A26131
Availability: In Stock
$290.00
-+
Reactivity: Human    
Applications: FC    
Host Species: Rabbit    
Isotype: IgG    
Clonality: Monoclonal Antibody    
Conjugation: APC. Ex:650nm. Em:660nm.
Gene Name: glypican 3
Gene Symbol: GPC3
Synonyms: SGB; DGSX; MXR7; SDYS; SGBS; OCI-5; SGBS1; GTR2-2
Gene ID: 2719
UniProt ID: P51654
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 481-580 of human Glypican 3 (GPC3) (NP_004475.1).
Dilution: FC,5 μl per 10^6 cells in 100 μl volume
Purification Method: Affinity purification
Concentration: 0.04 mg/ml
Buffer: PBS with 0.09% Sodium azide,0.2% BSA, pH7.3.
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Documents: Manual-GPC3 Antibody




Background

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants.




Images

GPC3  AntibodyFlow cytometry: 1×10^6 K-562 cells (negative control,left) and Hep G2 cells (right) were surface-stained with APC Rabbit anti-Human Glypican 3 (GPC3) mAb (A26131,5 μl/Test,orange line) or APC Rabbit IgG isotype control (A24173,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line).
Flow cytometry: 1×10^6 Hep G2 cells were surface-stained with APC Rabbit IgG isotype control (A24173,5 μl/Test,left) or APC Rabbit anti-Human Glypican 3 (GPC3) mAb (A26131,5 μl/Test,right).



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