APC Rabbit anti-Human/Monkey CD19 mAb (100 T)

APC Rabbit anti-Human/Monkey CD19 mAb (100 T)

Brand: Abclonal
Cat. #: A26220
Availability: In Stock
$88.00
-+
Reactivity: Human, Monkey    
Applications: FC    
Host Species: Rabbit    
Isotype: IgG    
Clonality: Monoclonal Antibody    
Conjugation: APC. Ex:650nm. Em:660nm.
Gene Name: CD19 molecule
Gene Symbol: CD19
Synonyms: N/A
Gene ID: 102145514
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-292 of monkey CD19 (XP_005591597.1).
Dilution: FC,5 μl per 10^6 cells in 100 μl volume
Purification Method: Affinity purification
Concentration: 0.04 mg/ml
Buffer: PBS with 0.09% Sodium azide,0.2% BSA, pH7.3.
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Documents: Manual-CD19 antibody




Background

This gene encodes a member of the immunoglobulin gene superfamily. Expression of this cell surface protein is restricted to B cell lymphocytes. This protein is a reliable marker for pre-B cells but its expression diminishes during terminal B cell differentiation in antibody secreting plasma cells. The protein has two N-terminal extracellular Ig-like domains separated by a non-Ig-like domain, a hydrophobic transmembrane domain, and a large C-terminal cytoplasmic domain. This protein forms a complex with several membrane proteins including complement receptor type 2 (CD21) and tetraspanin (CD81) and this complex reduces the threshold for antigen-initiated B cell activation. Activation of this B-cell antigen receptor complex activates the phosphatidylinositol 3-kinase signalling pathway and the subsequent release of intracellular stores of calcium ions. This protein is a target of chimeric antigen receptor (CAR) T-cells used in the treatment of lymphoblastic leukemia. Mutations in this gene are associated with the disease common variable immunodeficiency 3 (CVID3) which results in a failure of B-cell differentiation and impaired secretion of immunoglobulins. CVID3 is characterized by hypogammaglobulinemia, an inability to mount an antibody response to antigen, and recurrent bacterial infections. Alternative splicing results in multiple transcript variants encoding distinct isoforms.




Images

CD19 antibodyFlow cytometry: 1×10^6 Human PBMC were surface-stained with APC Rabbit IgG isotype control (A24173,5 μl/Test,left) or APC Rabbit anti-Human/Monkey CD19 mAb (A26220,5 μl/Test,right).



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