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Anti-ARHGAP17 Rabbit pAb (100 μl)
| Reactivity: | M & R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | ARHGAP17 rabbit polyclonal antibody |
Gene Name: | Rho GTPase-activating protein 17 |
Synonyms: | Neuron-associated developmentally-regulated protein, Nadrin, Rho-type GTPase-activating protein 17, Arhgap17, PP367, RICH1B, WBP15, RICH1, RhoGAP interacting with CIP4 homologs 1 |
Immunogen: | Recombinant protein corresponding to Mouse ARHGAP17 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Membrane |
Predicted MW. | 92 kDa |
Observed MW. | 81 kDa |
Uniprot ID: | Q3UIA2 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse | 1: 250-1: 500 | brain, placenta |
IHC/IF | Rat | 1: 500-1: 1500 | brain, heart |
Background
ARHGAP17 is a Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. It specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. RHGAP17 participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments.
Images
| Western blot analysis of Arhgap17 (GB112159) at dilution of 1: 250 |
| Immunohistochemistry of paraffin embedded rat brain using Arhgap17 (GB112159) at dilution of 1: 700 (400x lens) |
| Immunohistochemistry of paraffin embedded rat heart using Arhgap17 (GB112159) at dilution of 1: 700 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |