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| Reactivity: | Human, Mouse |
| Applications: | WB, ELISA |
| Host Species: | Rabbit |
| Clonality: | Monoclonal antibody |
| Gene Name: | ASPSCR1 tether for SLC2A4, UBX domain containing |
| Gene Symbol: | ASPSCR1 |
| Synonyms: | TUG; ASPL; ASPS; RCC17; UBXD9; UBXN9; ASPCR1; TUG/ASPSCR1 |
| Gene ID: | 79058 |
| UniProt ID: | Q9BZE9 |
| Clone ID: | 8I0U8 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human TUG/ASPSCR1 (Q9BZE9). |
| Dilution: | WB 1:500-1:1000 |
| Purification Method: | Affinity purification |
| Concentration: | 0.24 mg/ml |
| Buffer: | PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
| Documents: | Manual-ASPSCR1 antibody |
Background
The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membrane within minutes of insulin stimulation. Translocation t(X;17)(p11;q25) of this gene with transcription factor TFE3 gene results in a ASPSCR1-TFE3 fusion protein in alveolar soft part sarcoma and in renal cell carcinomas. Multiple alternatively spliced transcript variants have been found.
Images
 | Western blot analysis of various lysates, using TUG/ASPSCR1 Rabbit mAb (A1396) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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