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| Reactivity: | Mouse |
| Applications: | WB, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Polyclonal antibody |
| Gene Name: | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 |
| Gene Symbol: | ATP2A1 |
| Synonyms: | ATP2A; SERCA1; SERCA1/ATP2A1 |
| Gene ID: | 487 |
| UniProt ID: | O14983 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 901-1001 of human SERCA1/SERCA1/ATP2A1 (NP_775293.1). |
| Dilution: | WB 1:200-1:1000 |
| Purification Method: | Affinity purification |
| Concentration: | 1.45 mg/ml |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-ATP2A1 antibody |
Background
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms.
Images
 | Western blot analysis of lysates from C2C12 cells, using SERCA1/ATP2A1 Rabbit pAb (A10104) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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