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Anti-ATRAP Rabbit pAb (100 μl)
| Reactivity: | H,M & H |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Type-1 angiotensin II receptor-associated protein |
Synonyms: | AGTRAP, ATRAP |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse ATRAP |
Uniprot ID: | Q9WVK0 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Endoplasmic reticulum membrane, Golgi apparatus membrane, Cytoplasmic vesicle membrane |
Predicted MW. / Observed MW. | 18 kDa / 18 kDa |
Product Usage Information
WB | Human, Mouse | 1: 100-1: 300 | testis |
IHC/IF | Human | 1: 1000-1: 3000 | pancreas, cerebellum |
Background
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in angiotensin II-stimulated transcriptional activity. May play a role of negative regulator in cardiomyocyte hypertrophy induced by angiotensin II through an inhibition of p38 mitogen-activated protein kinase pathway.
Images
| Western blot analysis of AGTRAP (GB114824) at dilution of 1: 300 |
| Immunohistochemistry of paraffin embedded rat pancreas using AGTRAP (GB114824) at dilution of 1: 1000 |
| Immunofluorescence of paraffin embedded mouse cerebellum using AGTRAP (GB114824) at dilution of 1: 1000 |
| Immunofluorescence of paraffin embedded mouse cerebellum using AGTRAP (GB114824) at dilution of 1: 3000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |