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ABflo® 647 Rabbit anti-Human CD50(ICAM-3) mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 647. Ex:648nm. Em:664nm. |
| Gene Name: | intercellular adhesion molecule 3 |
| Gene Symbol: | ICAM3 |
| Synonyms: | CD50; CDW50; ICAM-R |
| Gene ID: | 3385 |
| UniProt ID: | P32942 |
| Clone ID: | 0P1F5 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-114 of human CD50(ICAM-3) (NP_002153.2). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.01 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-ICAM3 Antibody |
Background
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms.
Images
 | Flow cytometry: 1×10^6 Daudi cells (negative control,left) and U-937 cells (right) were surface-stained with ABflo® 647 Rabbit anti-Human CD50(ICAM-3) mAb (A25709,5 μl/Test,orange line) or ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 U-937 cells were surface-stained with ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,left) or ABflo® 647 Rabbit anti-Human CD50(ICAM-3) mAb (A25709,5 μl/Test,right). |
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