| Reactivity: | Mouse |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 700. Ex:690nm. Em:713nm. |
| Gene Name: | CD38 antigen |
| Gene Symbol: | Cd38 |
| Synonyms: | I-19; ADPRC 1; Cd38-rs1 |
| Gene ID: | 12494 |
| UniProt ID: | P56528 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 45-304 of mouse CD38 (NP_031672.2). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.02 mg/ml |
| Buffer: | PBS with 0.09% Sodium azide,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-Cd38 Antibody |
Background
This gene encodes a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Knockout mice deficient for this gene display altered humoral immune responses. In addition, knockout mice exhibit higher locomotor activity and defects in nurturing and social behaviors.
Images
![]() | Flow cytometry: 1×10^6 C2C12 cells (negative control,left) and C57BL/6 mouse splenocytes (right) were surface-stained with ABflo® 700 Rabbit anti-Mouse CD38 mAb (A26195,5 μl/Test,orange line) or ABflo® 700 Rabbit IgG isotype control (A25976,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
![]() | Flow cytometry: 1×10^6 C57BL/6 mouse splenocytes were surface-stained with ABflo® 700 Rabbit IgG isotype control (A25976,5 μl/Test,left) or ABflo® 700 Rabbit anti-Mouse CD38 mAb (A26195,5 μl/Test,right). |
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